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- 02-33664130
| 特聘教授 | |
| 沈立言教授/組長 | |
| 國立中興大學食品科學系學士、國立中興大學食品科學研究所碩士、國立中興大學食品科學研究所博士(含美國羅 | |
| lysheen@ntu.edu.tw | |
| 臺灣大學食品科技研究所 | |
| http://www.fst.ntu.edu.tw/teacher/sun/advisor.htm |
■研究方向
沈立言老師之研究欲結合中西醫食品營養的各家觀點與長處，利用細胞、動物與人體實驗模式進行保健食品與食療養生之相關研究，以提供人類養生保健之高附加價值食品。 研究分為4大組
自1993年起所執行之國科會、農委會及行政院衛生署研究計畫，主要利用細胞、動物與人體實驗模式，針對大蒜、九層塔、七層塔、牛樟芝、靈芝、巴西洋菇、薑、天麻、金針花等具有重要生理機能性之食品素材進行研究，包括肝臟解毒代謝、抗氧化、細胞代謝產物、抑癌、細胞凋亡、細胞週期、訊息傳遞、抗憂鬱、食物屬性等方向之探討。累積上述多年之研究經驗，期望將此等保健食品與食療養生之研究成果，對於提升人類的生活品質有所助益，且相關學術研究成果也獲業界的愛戴，歷年皆有機會和食品公司及生技公司合作，以利保健食品之認證與推廣。 人體試驗方面，利用脈診儀與甲襞微循環儀，測試不同體質的人對寒性及熱性食物之生理反應。探討傳統中醫食物分類與人體生理反應的相關性。 近期本食療研究室承蒙台大食品與分子生物研究中心江文章教授與愛之味公司總裁陳哲芳先生及研發總監陳冠翰博士大力支持得以將本食療研究室傳統中醫食療抗憂鬱研究得以產品化，以期實能將研究成果與日常生活做結合。 |
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現職：
國立臺灣大學 國家食品安全教育暨研究中心主任 國立臺灣大學 食品與生物分子研究中心主任 國立台灣大學 食品科技研究所教授 Journal of Traditional and Complementary Medicine總編輯 臺灣食品保護協會理事長 臺灣傳統暨互補醫學協會 理事長 考試院考選部 典試委員及命題委員 ISRN Toxicology Journal編輯委員 Journal of Food and Drug Analysis編輯委員 Food Science and Human Wellness編輯委員 European Journal of Toxicological Sciences編輯委員 食品藥物管理署 食品藥物化粧品審查委員會委員 食品藥物管理 署 健康食品審議委員會委員 食品藥物管理 署 廣告標示審議委員會召集人 食品藥物管理 署 健康食品及膠囊錠狀食品非預期反應諮議委員會委員 經濟部工業局 CITD民生食品類組召集人 經濟部工業局 中小業即時技術輔導委員 國家科學委員會 保健營養學門 初審及複審委員 台灣保健食品學會 理事 台灣營養學會 理事 台灣食品科技學會 理事 103年度衛生福利部政策白皮書 (財團法人台灣醫界聯盟基金會) 食品藥物管理小組 召集人 海峽兩岸學術文化交流協會 副理事長 海峽兩岸學術文化交流協會 保健食品研究會 會長 經歷經濟部工業局 CITD民生食品類組 委員 經濟部工業局 中小企業即時技術輔導 召集人 台灣營養學會 副秘書長 台灣營養學會 理事 國立臺灣大學 食品科技研究所副教授 台灣保健食品學會 常務理事 中國醫藥學院 營養學系暨醫學營養學系系主任 台中市營養公會 理事 海峽兩岸學術文化交流協會 保健食品研究會副會長 中國醫藥學院 營養學系副教授 |
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■期刊論文
Lai, Y.S., Chen, W.C., Ho, C.T., Lu, K.H., Lin, S.H., Tseng, H.C., and Sheen, L.Y.* 2014.Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress. Journal of Agricultural and Food Chemistry (revised, SCI)
Liu, Y.T., Lo, Y.C., Hsieh, S.C., Sheen, L.Y.* 2014. The antioxidant activity of blackcurrant and its effects on Parkinson's disease and Alzheimer's disease. Nutritional Science Journal. (in press)
Lu, K.H., Tseng, H.C., Liu, C.T., Huang, C.J., Chyuanc, J.H., Sheen, L.Y.* 2014. Wild bitter gourd protects against alcoholic fatty liver in mice by attenuating oxidative stress and inflammatory responses. Food and Function 5(5): 1027-1037. (SCI)
Chu, Y.L., Chimeddulam, D, Sheen, L.Y, and Wu, K.Y. 2013. Probabilistic risk assessment of exposure to leucomalachite green residues from fish products. Food and Chemical Toxicology 62: 770-776. (SCI)
Liu, C.T., Raghu, R., Lin, S.H., Wang, S.Y., Kuo, C.H., Tseng, Y.J., Sheen, L.Y.* 2013. Metabolomics of ginger essential oil against alcoholic fatty liver in mice. Journal of Agricultural and Food Chemistry 61(46): 11231-11240. (SCI)
Chu, Y.L., Raghu, R., Lu, K.H., Liu, C.T., Lin, S.H., Lai, Y.S., Chen, W.C., Lin, S.H., andSheen, L.Y.* 2013. REVIEW ARTICLE: Autophagy Therapeutic Potential of Garlic in Human Cancer Therapy. Journal of Traditional and Complementary Medicine 3(3): 159-162. (PubMed)
Chu, Y.L., Ho, C.T., Chung, J.G., Raghu, R., Lo, Y.C., and Sheen, L.Y.* 2013. Allicin induces anti-human liver cancer cells through p53 gene modulating apoptosis and autophagy. Journal of Agricultural and Food Chemistry 61, 9839-9848. (SCI)
Chen, S.F., Hu, T.M., Lan, T.H., Chiu, H.J., Sheen, L.Y.*, Loh, E.W. 2013. Severity of psychosis syndrome and change of metabolic abnormality in chronic schizophrenia patients: Severe negative syndrome may be related to a distinct lipid pathophysiology. European Psychiatry 29(3): 167-171. (SCI)
Lin, S.H., Chang, H.C., Chen, P.J., Hsieh, C.L., Su, K.P., and Sheen, L.Y.* 2013. The antidepressant-like effect of ethanol extract of daylily flowers (金針花 Jīn Zhēn Huā ) in rats.Journal of Traditional and Complementary Medicine 3(1): 53-61. (PubMed)
Hao, C.W., Lai, W.S., Ho, C.T., and Sheen, L.Y.* 2013. Antidepressant-like effect of lemon essential oil is through a modulation in the levels of norepinephrine, dopamine, and serotonin in mice: use of the tail suspension test. Journal of Functional Foods 5: 370-379. (SCI)
Raghu R., Liu, C.T., Tsai, M.H., Tang, X., Kalari, K.R., Subramanian, S., and Sheen, L.Y.*2012. Transcriptome analysis of garlic induced hepatoprotection against alcoholic fatty liver.Journal of the Agricultural and Food Chemistry 60(44): 11104-11119. (SCI)
Wu, C.C., Chu, Y.L., and Sheen, L.Y.* 2012. Allicin modulates the antioxidation and detoxification capability in primary rat hepatocytes. Journal of Traditional and Complementary Medicine 2(4): 323-330. (PubMed)
Su, Y.C., Liu, C.T., Raghu, R., Kuo, Y.H., and Sheen, L.Y.* 2012. Eburicoic acid, an active triterpenoid from the fruiting bodies of basswood cultivated Antrodia cinnamomea, induces ER stress-mediated autophagy in human hepatoma cells. Journal of Traditional and Complementary Medicine 2(4): 312-322. (PubMed)
Liu, Y.W., Lu, K.H., Ho, C.T., and Sheen, L.Y.* 2012. Protective effects of Antrodia cinnamomea against liver injury. Journal of Traditional and Complementary Medicine 2(4):284-294. (PubMed)
Wang H.C., Pao, J., Lin, S.Y., and Sheen, L.Y.* 2012. Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression. Annals of the New York Academy of Sciences 1271(1): 44-52. (SCI)
Chu, Y.L., Ho, C.T., Chung, J.G., Raghu, R., and Sheen, L.Y.* 2012. Allicin induces p53-mediated autophagy in Hep G2 human liver cancer cells. Journal of the Agricultural and Food Chemistry 60(34): 8363-8371. (SCI)
Raghu, R., Lu, K.H., and Sheen, L.Y.* 2012. Recent research progress on garlic (大蒜 dà suàn) as a potential anticarcinogenic agent against major digestive cancers. Journal of Traditional and Complementary Medicine 2(3): 192-201. (PubMed)
Lu, K.H., Liu, C.T., Raghu, R., and Sheen, L.Y.* 2012. Therapeutic potential of Chinese herbal medicines in alcoholic liver disease. Journal of Traditional and Complementary Medicine 2(2): 115-122. (PubMed)
Liu, C.T., Hsu, T.W., Chen, K.M., Tan, Y.P., Lii, C.K., and Sheen, L.Y. 2012. The antidiabetic effect of garlic oil is associated with ameliorated oxidative stress but not ameliorated level of pro-inflammatory cytokines in skeletal muscle of streptozotocin-induced diabetic rats. Journal of Traditional and Complementary Medicine 2(2): 135-144. (PubMed)
Tsai, C.W., Chen, H.W., Sheen, L.Y., and Lii, C.K. 2012. Garlic: Health benefits and actions.BioMedicine 2(1): 17-29.
Tung, Y.C., Su, Z.Y., Kuo, M.L., and Sheen, L.Y.* 2012. Ethanolic extract of Agaricus blazeifermentation product inhibits the growth and invasion of human hepatoma HA22T/VGH and SK-Hep-1 cells. Journal of Traditional and Complementary Medicine 2(2): 145-153.(PubMed)
Chen, I.S., Chen, Y.C., Chou, C.H., Chuang, R.F., Sheen, L.Y., and Chiu, C.H. 2012. Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis. Journal of the Science of Food and Agriculture 92(7): 1441-1447. (SCI)
Wang, H.C., Hsieh, S.C., Yang, J.H., Lin, S.Y., and Sheen, L.Y.* 2012. Diallyl trisulfide induces apoptosis of human basal cell carcinoma cells via endoplasmic reticulum stress and the mitochondrial pathway. Nutrition and Cancer 64(5): 770-780. (SCI)
Chen, P.J., Pang, V.F., Jeng, Y.M. Chen, T.J., Hu, F.C., Chi, W.T., Chou, H.Y., Chiu, H.C., Lee, Y.C., and Sheen, L.Y.* 2012. Establishment of a standardized animal model of chronic hepatotoxicity using acetaminophen-induced hepatotoxicity in the evaluation of hepatoprotective effects of health food. Journal of Food and Drug Analysis 20(1): 43-49. (SCI)
Chen, I.S., Chen, Y.C., Chou, C.H., Chuang, R.F., Sheen, L.Y.and Chiu, C.H. 2011.Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis. Journal of the Science of Food and Agriculture 92: 1441-1447. (SCI)
Wang, Y.W., Lii, C.K., Sheen, L.Y., and Liu, C.T. 2011. The effect of garlic oil on insulin secretion in HIT-T15 cells. Nutritional Science Journal 36 (4): 29-39. (中華民國營養學會雜誌)
Chao, D.P., Tyan, C.C., Chen, J.J., Hsieh, C.L., and Sheen, L.Y.* 2011. Effect of hot-attribute aged ginger tea on Chinese medical pulse condition of healthy young humans. Journal of Traditional and Complementary Medicine 1(1): 69-75. (PubMed)
Chen, P.J. and Sheen, L.Y.* 2011. Gastrodiae Rhizoma (天麻 tiān má): a review of biological activity and antidepressant mechanisms. Journal of Traditional and Complementary Medicine 1(1): 31-40. (PubMed)
Chao, D.P., Chen, J.J., Huang, S.Y., Tyan C.C., Hsieh C.L., and Sheen, L.Y.* 2011. Effects of hot and cold foods on signals of heart rate variability and nail fold microcirculation of healthy young humans: a pilot study. Chinese Journal of Physiology 54(3): 145-152. (SCI)
Su, Z.Y., Tung, Y.C., Hwang, L.S., and Sheen, L.Y.* 2011. Blazeispirol A from Agaricus blazei fermentation product induces cell death in human hepatoma Hep 3B cells through caspase-dependent and caspase-independent pathways. Journal of the Agricultural and Food Chemistry 59(9): 5109-5116. (SCI)
Chen, P.J., Liang, K.C., Lin, H.C., Hsieh, C.L., Su, K.P., Hung M.C., and Sheen, L.Y.* 2011.Gastrodia elata Bl. Attenuated learning deficits induced by forced-swimming stress in the inhibitory avoidance task and Morris water maze. Journal of Medicinal Food 14(6): 610-617.(SCI)
Chi, H.M., Chou, S.T., Lin, S.C., Su, Z.Y., and Sheen, L.Y.* 2010. Protective effects of water extract of clam on normal and CCl4-induced damage in primary rat hepatocytes. The American Journal of Chinese Medicine 38(6): 1193-1205. (SCI)
Liao C.L., Huang H.Y., Sheen L.Y., and Chou, C.C. 2010. Anti-inflammatory activity of soymilk and fermented soymilk prepared with lactic acid bacterium and bifidobacterium.Journal of Food and Drug Analysis 18(3): 202-207. (SCI)
Wang, H.C., Yang, J.H., Hsieh S.C., and Sheen, L.Y.* 2010. Allyl sulfides inhibit cell growth of skin cancer cells through induction of DNA damage mediated G2/M arrest and apoptosis. Journal of the Agricultural and Food Chemistry 58(11): 7096-103. (SCI)
Lin, Y.W., Pan, J.H., Sheen, L.Y., Liu, R.H., Kuo, Y.H., and Chiang, B.H. 2010. The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells. Journal of the Science of Food and Agriculture 90(10): 1739-1744. (SCI)
Lin, S.Y., Sheen, L.Y., Chiang, B.H., Yang, J.S., Pan, J.H., Chang, Y.H., Hsu, Y.M., Chiang, J.H., Lu, C.C., Wu, C.L., and Chung, J.G. 2010. Dietary effect of Antrodia camphorateextracts on immune responses in WEHI-3 leukemia BALB/c mice . Nutrition and Cancer62(5): 593-600. (SCI)
Wang, Y.J., Sheen, L.Y., and Chou, C.C. 2010. Storage effects on the content of anthocyanin, mutagnicity and antimutagenicity of black soybean koji. International Journal of Food Science and Technology 43(4): 702-707. (SCI)
Lei, Y.P., Liu, C.T., Sheen, L.Y., Chen H.W., and Lii, C.K. 2010. Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein. Molecular Nutrition and Food Research 54(suppl 1): S42-52. (SCI)
Huang, R.Y., Wang, Y.J., Sheen, L.Y., and Chou, C.C. 2010. Storage temperature and packaging condition affect the total phenolic content and antioxidant activity of black soybeans and koji. International Journal of Food Science and Technology 45(3): 437-443. (SCI)
Chen, P.J., Hsieh, C.L., Su, K.P., Hou, Y.C., Jiang, X.M., Lin, I.H., and Sheen, L.Y.* 2009.Rhizomes of Gastrodia elata Bl. possess antidepressant-like effect via monoamine modulation in subchronic animal model. The American Journal of Chinese Medicine 37(6): 1113-1124. (SCI)
Chen, Y.K., Kuo, Y.H., Chiang, B.H., Lo, J.M., and Sheen, L.Y.* 2009. Cytotoxic activities of 9,11-dehydroergosterol peroxide and ergosterol peroxide from the fermentation mycelia ofGanoderma lucidum cultivated in the medium containing leguminous plants on Hep 3B cells. Journal of the Agricultural and Food Chemistry 57(13): 5713-5719. (SCI)
Liu, C.T., Su, H.M., Lii, C.K., and Sheen, L.Y. 2009. Effect of supplementation with garlic oil on activity of Th1 and Th2 lymphocytes from rats. Planta Medica 75(3): 205-210. (SCI)
Pan, J.H., Chen, Y.S., Sheen, L.Y., and Chiang, B.H. 2008. Large-scale submerged fermentation of Antrodia cinnamomea for anti-hepatoma activity. Journal of the Science of Food and Agriculture 88: 2223-2230. (SCI)
Su, Z.Y., Hwang, L.S., Kuo, Y.H., Shu, C.H., and Sheen, L.Y.* 2008. Black soybean promotes the formation of active components with antihepatoma activity in the fermentation product of Agaricus blazei. Journal of the Agricultural and Food Chemistry 56(20): 9447-9454. (SCI)
Lei, Y.P., Chen, H.W., Sheen, L.Y., and Lii, C.K. 2008. Diallyl disulfide and diallyl trisulfide suppress oxidized LDL-induced vascular cell adhesion molecule and E-selectin expression through protein kinase A- and B-dependent signaling pathways. The Journal of Nutrition138(6): 996-1003. (SCI)
Chen, Y.S., Pan, J.H., Chiang, B.H., and Sheen, L.Y.* 2008. Ethanolic extracts of Antrodia cinnamomea mycelia fermented at varied times and scales have differential effects on hepatoma cells and normal primary hepatocytes. Journal of Food Science 73(7): H179-H185.(SCI)
Chen, P.J., Hsieh, C.L., Su, K.P., Hou, Y.C., Jiang, X.M., Lin, I.H., and Sheen, L.Y.* 2008.The antidepressant effect of Gastrodia elata Bl. on the forced-swimming test in rats. The American Journal of Chinese Medicine 36(1): 95-106. (SCI)
Liu, C.T., Sheen, L.Y., and Lii, C.K. 2007. Does garlic have a role as antidiabetic agent?Molecular Nutrition and Food Research 51(11): 1353-1364. (SCI)
Tsai, C.W., Chen, H.W., Yang, J.J., Sheen, L.Y., and Lii, C.K. 2007. Diallyl disulfide and diallyl trisulfide up-regulate the expression of the π class of glutathione S-transferase via an AP-1-dependent pathway. Journal of the Agricultural and Food Chemistry 55(3): 1019-1026. (SCI)
Liu, K.L., Chen, H.W., Wan, R.Y., Lei, Y.P., Sheen, L.Y., and Lii, C.K. 2006. DATS reduces LPS-induced iNOS expression, NO production, oxidative stress and NF-κB activation in RAW 264.7 macrophages. Journal of the Agricultural and Food Chemistry 54(9): 3472-3478. (SCI)
Lin, W.C., Liao, Y.C., Liau, M.C., and Sheen, L.Y.* 2006. Inhibitory effect of CDA-II, a urinary preparation, on alflatoxin B1-induced DNA damage in primary rat hepatocytes. Food and Chemical Toxicology 44(4): 546-551. (SCI)
Tsai, C.W., Yang, J.J., Chen, H.W., Sheen, L.Y., and Lii, C.K. 2005. Garlic organosulfur compounds up-regulate the expression of the π class of glutathione S-transferase in rat primary hepatocytes. Journal of Nutrition 135(11): 2560-2565. (SCI)
Liu, C.T., Hse, H., Lii, C.K., Chen, P.S., and Sheen, L.Y. 2005. Effect of garlic oil and diallyl trisulfide on glycemic control in streptozotocin-induced diabetic rats. European Journal of Pharmacology 516(2): 165-173. (SCI)
Yang, J.H., Chou, C.C., Cheng, Y.W., Sheen, L.Y., Chou, M.C., Yu, H.S., Wei, Y.H., andChung, J.G. 2004. Effects of glycolic acid on the induction of apoptosis via caspase-3 activation in human leukemia cell line (HL-60). Food and Chemical Toxicology 42(11): 1777-1784. (SCI)
Wu, C.C., Chung, J.G., Tsai, S.J., and Sheen, L.Y.* 2004. Differential effects of allyl sulfides from garlic essential oil on cell cycle regulation in human liver tumor cells. Food and Chemical Toxicology 42(12): 1937-1947. (SCI)
Wu, C.C., Lii, C.K., Tsai, S.J., and Sheen, L.Y.* 2004. Diallyl trisulfide modulates cell viability and the antioxidation and detoxification systems of rat primary hepatocytes. Journal of Nutrition 134 (4): 724-728. (SCI)
Kao, M.J. and Sheen, L.Y.* 2003. Effects of infrared and low-power laser irradiation on cell viability, glutathione and glutathione-related enzyme activities in primary rat hepatocytes.Journal of Formosa Medicine Association 102(7): 486-491. (SCI)
Lin, W.C., Liao, Y.C. Liau, M.C., and Sheen, L.Y.* 2003. Effect of CDA-II on cell viability, lipidperoxidation, glutathione concentration and its related enzyme activities in primary rat hepatocytes. The American Journal of Chinese Medicine 31(3): 415-423. (SCI)
Wu, C.C., Sheen, L.Y., Chen, H.W., Kuo, W.W., Tsai, S.J., and Lii, C.K. 2002. Differential effects of garlic oil and its three major organosulfur components on the hepatic detoxification system in rats. Journal of the Agricultural and Food Chemistry 50: 378-383. (SCI)
Chen, H.W., Yang, J.J., Tsai, C.W., Wu, C.C., Sheen, L.Y., Ou, C.C., and Lii, C.K. 2001. Dietary fat and garlic oil independently regulate hepatic cytochrome P450 2B1 and the placental form of glutathione S-transferase expression in rats. Journal of Nutrition 131: 1438-1443. (SCI)
Sheen, L.Y.*, Wu, C.C., Lii, C.K., and Tsai, S.J. 2001. Effect of diallyl sulfide and diallyl disulfide, the active principles of garlic, on the alflatoxin B1-induced DNA damage in primary rat hepatocytes. Toxicology Letters 122(1): 45-52. (SCI)
Chen, C.C., Wang, H.J., Shih, H.C., Sheen, L.Y., Chang, C.T., Chen, R.H., and Wang, T.Y.2001. Comparison the metabolic effects of metformin and troglitazone on fructose-induced insulin resistance in male Sprague-Dawley rats. Journal of Formosa Medicine 100(3): 176-180. (SCI)
Wu, C.C., Sheen, L.Y., Chen, H.W., Tsai, S.J., and Lii, C.K. 2001. Effect of organosulfur compounds from garlic oil on the antioxidation system in rat liver and red blood cells. Food and Chemical Toxicology 39(6): 563-569. (SCI)
Sheen, L.Y., Chen, H.W., Kung, Y.L., Liu, C.T., and Lii, C.K. 1999. Effects of garlic oil and its organosulfur compounds on the activities of hepatic drug-metabolizing and antioxidant enzymes in rats fed high- and low-fat diets. Nutrition and Cancer 35(2): 160-166. (SCI)
Sheen, L.Y.*, Wu, C.C., Lii, C.K., and Tsai, S.J. 1999. Metabolites of diallyl disulfide and diallyl sulfide in primary rat hepatocytes. Food and Chemical Toxicology 37(12): 1139-1146. (SCI)
Sheen, L.Y.*, Sheu, S.F., Tsai, S.J., Meng, R.H.C., and Lii, C.K. 1999. Effect of garlic active principle – diallyl disulfide – on cell viability, lipid peroxidation, glutathione concentration and its related enzyme actives in primary rat hepatocytes. The American Journal of Chinese Medicine 27 (1): 95-105. (SCI)
林淑媛、許靖宜、陳宇嘉、張錦文、沈立言*。1998。醫院營養師對醫院營養部伙食外包廠商考考量及品質之看法。中國醫藥學院雜誌 7(4): 127-134.
許靖宜、林淑媛、陳宇嘉、張錦文、沈立言*。1998。醫院營養師對於伙食外包可行性之研究。中國醫藥學院雜誌 7(3): 173-182.
Liu, C.T., Chen, H.W., Sheen, L.Y., Kung, Y.L., Chen, P.C.H., and Lii, C.K. 1998. Effect of garlic oil on hepatic arachidonic acid content and immune response in rats. Journal of the Agricultural and Food Chemistry 46: 4642-4647. (SCI)
Chen, H.W., Lii, C.K., Wu, M.H., Ou, C.C., and Sheen, L.Y. 1997. Amount and type of dietary lipid modulate rat hepatic cytochrome P-450 activity. Nutrition and Cancer 29: 174-180. (SCI)
Lin, C.W., Lin, T.H., Sheen, L.Y., Chung, C.H., and Cheng, K.S. 1997. Diallyl sulfide as a potent inducer on the granulocytic/ macrophagic differentiation of K562 human leukemic cells. Med. J. CMCH 2: 149-154.
葉佳聖、沈立言、李宗貴、蔡順仁。1997。補骨脂水萃取物及補骨脂酚對大白鼠初代肝細胞之抗氧化保護作用。中華民國營養學會雜誌 22(3): 303-324.
Wang, S.T., Chen, H.W., Sheen, L.Y., and Lii, C.K. 1997. Methionine and cysteine affect glutathione level, glutathione-related enzyme activities and the expression of glutathione S-transferase isozymes in rat hepatocytes. The Journal of Nutrition 127: 2135-2141. (SCI)
Chen, H.W., Ko, J.J., Lii, C.K., Ou, C.C., and Sheen, L.Y. 1997. Corn oil enhance r-glutamyl transpeptidase-positive foci development in the present of amphorateal during hepatocarcinogenesis in rats. Nutrition and Cancer 28 (3): 252-257. (SCI)
葉佳聖、沈立言、蔡順仁。1997。補骨脂酚對大白鼠初代肝細胞之抗氧化生理活性之影響。食品科學 24(3): 295-307.
沈立言、吳志忠。1997。大蒜素於 45oC下在不同油脂中之變化。中華民國營養學會雜誌 22(1): 89-102.
Sheen, L.Y.*, Lii, C.K., Sheu, S.F., Meng, R.H.C., and Tsai, S.J. 1996. Effect of the active principle of garlic – diallyl sulfide – on the cell viability, detoxification capability and antioxidation system of primary rat hepatocytes. Food and Chemical Toxicology 34: 971- 978. (SCI)
Lii, C.K., Wang, S.T., Chen, H.W., and Sheen, L.Y. 1996. Glutathione and glutathione-related enzyme activities of male and female rat hepatocytes under various culture conditions.Archives of Toxicology 70: 822-829. (SCI)
沈立言、吳志忠、蔡順仁。1995。大蒜精油在不同油脂中之安定性。中華民國營養學會雜誌20(4): 381-392.
沈立言、呂英震、康志強、林淑媛、蔡順仁。1994。大蒜保健食品中活性成分之定性及定量分析。中華民國營養學會雜誌 19(4): 395-406.
Lin, S.Y., Sheen, L.Y., and Tsai, S.J. 1994. Effect of microwave-heating on retention and composition of basil oil. Food Science 21(1): 75-82.
林淑媛、沈立言、蔡順仁。1992。蒜、薑精油微膠囊在儲藏後之香味變化。中國農業化學會誌 30(4): 544-552.
沈立言、林淑媛、蔡順仁。1992。利用相分離法製備精油微膠囊及其性質之探討。中國農業化學會誌 30(3): 307-320.
沈立言、林淑媛、蔡順仁。1992。不同精油添加量對於噴霧乾燥精油微膠囊品質之影響。食品科學 19(2): 217-229.
沈立言、林淑媛、蔡順仁。1992。以氣相層析儀嗅聞法進行蒜及薑精油揮發性成分香氣之評估。中國農業化學會誌 30(1): 14-24.
沈立言、林淑媛、蔡順仁。1991。不同精油含量之羅勒、蒜、薑精油微膠囊之製備及其精油成分在噴霧乾燥過程中之變化。食品科學18(4): 344-355.
沈立言、蔡順仁。1991。薑、羅勒、蒜噴霧乾燥精油膠囊之製備及其性質之研究。中國農業化學會誌 29(2): 226-237.
Sheen, L.Y., Tsai Ou, Y.H., and Tsai, S.J. 1991. Flavor characteristic compounds found in the
essential oil of Ocimum basilicum L. with sensory evaluation and statisticalanalysis.Journal of the Agricultural and Food Chemistry 39: 939-943. (SCI)
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